Stefan Linder
| Address: | Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten
Pettenkoferstr.9 80336 München GERMANY |
| Phone: | +49 89 5160 4371 |
| Fax: | +49 89 5160 4382 |
| Email: | stefan.linder@med.uni-muenchen.de |
| Website: | klp.web.med.uni-muenchen.de... |
Research Interests
Our lab investigates podosomes in primary human cells. The aim of these studies is to elucidate the role of podosomes in physiological (immune cell migration, angiogenesis) and pathological contexts (atherosclerosis, endothelial dysfunction).
We are particularly interested in the regulation of podosome dynamics (formation, fusion/fission, dissolution) in macrophages. Here, we focus on functional interactions between podosomes and microtubules, and on the delivery of regulatory factors through microtubule-based motor proteins to podosomes. Another focus in the lab is on podosome formation and function in endothelial cells, especially in regard to wound healing and endothelial integrity. Finally, we study the mechanisms of podosome-dependent matrix degradation through delivery and regulation of matrix-degrading enzymes.